Dị ka otu n'ime ihe ndị a na-ejikarị eme ihe na usoro ọgwụ, ihe nrịbawanye nke capsules gelatin bụ njirimara anụ ahụ bụ isi nke na-emetụta ọnụego ntọhapụ ọgwụ na bioavailability. Ọzịza na-ezo aka n'ihe a na-eme ebe shei capsule na-amịkọrọ mmiri ma na-enwe mmụba olu ma ọ bụrụ na a na-akpọtụrụ onye na-ahụ maka mmiri. Usoro a na-ekpebi kpọmkwem oge mgbasa capsule na omume mgbasa ọgwụ.
Enwere ike ikewa usoro ọzịza nke capsules gelatin ụzọ atọ: ọkwa mbụ nke mmiri mmiri, ọkwa ọzịza ngwa ngwa, na ọkwa nrịba nke nha. Mgbe capsule na-abanye na kọntaktị na mmiri mmiri, ìgwè hydrophilic dị na agbụ molekụla gelatin (dị ka -COOH na -NH2) na-etolite ngwa ngwa hydrogen na ụmụ irighiri mmiri, na-ete elu capsule. Na-esote, ụmụ irighiri mmiri na-abanye n'usoro netwọkụ dị n'akụkụ atọ nke gelatin site na osmosis, na-ebute mmụba n'ebe dị anya n'etiti ụdọ molekụla na mmụba dị ukwuu na olu capsule. Nnyocha egosila na na ogo 37, ogo ọzịza nke capsules gelatin nwere ike iru 200%{10}}300%, n'ikpeazụ na-akpụzi ihe owuwu gel.
Ihe na-emetụta ọzịza nke capsules gelatin efu na-agụnyekarị isi iyi gelatin, ogo nke obe{0}njikọ, ọnọdụ okpomọkụ, na ọkara pH. Ebe anụmanụ dị iche iche (dị ka akpụkpọ anụ porcine, zoon bovine, ma ọ bụ ọkpụkpụ azụ) na-ebute mgbanwe dị iche iche na nhazi amino acid na nkesa molekụla dị arọ nke gelatin, nke na-emetụta ikike ịmị mmiri ya ozugbo. obe na-agafeghị oke{3}njikọ nwere ike welie ike nrụzi nke capsule, mana ngafe oke{4}}njikọ nwere ike igbochi ntinye mmiri wee belata ọzịza. Mmụba nke okpomọkụ na-eme ka mmegharị ahụ dị ngwa ngwa ma na-akwalite usoro ọzịza, ebe gburugburu acidic ma ọ bụ alkaline nwere ike gbanwee ọnọdụ ụgwọ nke ụdọ molekul gelatin, na-emetụta hydration ha.
Na ngwa bara uru, ọzịza nke capsules gelatin nwere mmetụta abụọ na mwepụta ọgwụ. N'otu aka, ọzịza kwesịrị ekwesị na-eme ka o doo anya na capsule na-agbasa ngwa ngwa na tract gastrointestinal, na-akwalite mgbasa nke ọgwụ. N'aka nke ọzọ, ọzịza ngwa ngwa gabigara ókè nwere ike ibute ntupu ọgwụ, ebe ọzịza ezughi oke nwere ike ibute ntọhapụ ọgwụ ezughị ezu. Ya mere, site n'ịgbanwe ụdị gelatin, na-agbakwunye plasticizers (dị ka glycerin), ma ọ bụ na-ejikọta surfactants, omume ọzịza nke capsules nwere ike ịchịkwa nke ọma iji gboo mkpa ntọhapụ nke ọgwụ dị iche iche.
Site n'ọganihu nke teknụzụ imepụta ihe, nyocha banyere ọzịza nke capsules gelatin esiwo n'ihe ịtụnanya macroscopic gaa n'usoro mkpụrụ ndụ. Ngwa nke usoro nyocha nke ọgbara ọhụrụ, dị ka Icheiche Scanning Calorimetry (DSC) na Dynamic Mechanical Analysis (DMA), enyela ngwaọrụ dị ike maka ikpughe mgbanwe mgbanwe na ụdọ molekụla n'oge usoro ọzịza. N'ọdịnihu, site na injinia mkpụrụ ndụ ihe nketa nke gelatin gbanwere ma ọ bụ imepụta ihe mejupụtara ya na polymers eke, a na-atụ anya na a ga-emepụta sistemu capsule ọhụrụ nwere nzaghachi ọzịza nwere ọgụgụ isi, na-aga n'ihu na-aga n'ihu na teknụzụ nnyefe ọgwụ. Ọ bụrụ na enwere ihe ọ bụla chọrọ na capsules efu, nabata ịkpọtụrụKornnacCaps.
